Cannabis Science — The Endocannabinoid System: How cannabis oil works.
Since 1974 studies have shown that cannabis has anti-tumor effects. The results of the 1974 study, reported in an Aug. 18, 1974, Washington Post newspaper feature, were that cannabis’s component, THC, “slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent.” In 1975 an article in the Journal of the National cancer institute titled “Antineoplastic Activity of Cannabinoids,” they reported that “Lewis lung adenocarcinoma growth was retarded by the oral administration of tetrahydrocannabinol (THC) and cannabinol (CBD). Mice treated for 20 consecutive days with THC and CBD had reduced primary tumor size.”
In 1998, a research team at Madrid’s Complutense University Led by Dr. Manuel Guzman discovered that THC can selectively induce programmed cell death in brain tumor cells without negatively impacting surrounding healthy cells. They reported in the March 2002 issue of “Nature Medicine” they had destroyed incurable brain cancer tumors in rats by injecting them with THC. And in 2007 even Harvard Researchers found that compounds in cannabis cut the growth of lung cancer. There is also an organization called The SETH Group that showed compounds in cannabis can stop the growth of human glioblastoma multiforma (GBM) brain cancer cells. The SETH Group says “No chemotherapy can match this nontoxic anti-cancer action.” Even last year in 2012 a pair of scientists at California Pacific Medical Center in San Francisco found THC stops metastasis in many kinds of aggressive cancer.
He’s only 3 years old, but Landon Riddle is already the focus of a medical marijuana fight in Colorado.
Landon has acute lymphocytic leukemia, or ALL, a cancer of the blood and bone marrow. It’s the most common cancer in children.
His mother says his condition has improved so much following treatment with medical marijuana that chemotherapy isn’t needed. But the Children’s Hospital of Colorado, she says, disagreed.
It all started back in September 2012. Landon, then 2, was living with his mother, Sierra Riddle, in St. George, Utah, when he developed a sore throat and swollen lymph nodes. The emergency room doctor said it was a virus and sent him home.
School stops giving boy medical pot Is medical marijuana right for a 3-year-old? “Please don’t let my daughter die”
Two days later he went back. His armpits were swollen.
“They thought it was either a virus or infection in the lymph nodes, so they gave him some antibiotics,” Sierra Riddle says.
But on the fifth day, his mother says she was changing his diaper and noticed his groin was also swollen, as well as his abdomen and throat. He was having trouble breathing.
That time, she got a frightening diagnosis: cancer.
New York governor announces plan for medical marijuana at hospitals
Landon was flown to a children’s hospital in Salt Lake City.
“His whole chest was full of leukemia tumors, which is why he couldn’t breathe,” his mother says. “They started him on chemo, but told us that he probably wasn’t going to make it.”
Landon’s cancer had quickly progressed, leading doctors to give him an 8% chance of survival, she says.
In general, ALL is one of the most curable cancers. According to the American Cancer Society, more than 90% of children diagnosed with the disease survive.
Chemotherapy is the standard treatment, and Riddle says doctors put Landon on a four-year treatment plan. The first two months of chemo went fairly well, but then Landon became extremely ill.
“Most days he couldn’t get off the couch,” Riddle remembers. “He would just lay there and throw up and throw up.”
Riddle says he also developed neuropathy — a symptom of nerve damage that can cause weakness, numbness and pain — in his legs that left him barely able to walk.
Around that time, a friend set up a Facebook page called Offer Hope for Landon, and recommendations started streaming in, including several endorsing cannabis — medical marijuana — as a treatment.
Medical marijuana, however, isn’t legal in Utah. Still, desperate for answers, Sierra Riddle and her mother, Wendy Riddle, started looking into it.
They considered going to California or Oregon. Then their research led them to the Stanley brothers in Colorado. The six brothers are one of that state’s biggest cannabis growers and dispensary owners.
The Stanleys produce about 500 pounds of medical marijuana a year. At the time, much of it was high in THC — tetrahydrocannabinol, the psychoactive ingredient in pot that gets users high but also helps patients with an array of conditions including pain and nausea.
But the Stanleys were also growing something quite revolutionary: a plant cross-bred to reduce the THC and increase another compound found in cannabis called cannabidiol, or CBD. Many researchers believe CBD is one of the compounds in marijuana that has medicinal benefits. According to the National Cancer Institute, it’s thought to have significant analgesic, anti-inflammatory and anti-tumor activity without the psychoactive effect.
The Stanleys expect to produce over 1,000 pounds this year, most of it the cross-bred variety, according to Joel Stanley.
Dr. Sanjay Gupta: Why I changed my mind on weed
Riddle, herself a recovering heroin addict, struggled with the idea of giving Landon marijuana.
“I was telling my mom, you know, ‘We really need to think about this.'”
But, says Riddle, her son was already prescribed medications like OxyContin and morphine — medications with significant side effects.
Landon suffered from stomach failure, and “the OxyContin made him so miserable, when he had hair, he would literally try to pull his hair out.”
In the end, she decided she had nothing else to lose and moved to Colorado. She rented a room, got Landon’s medical marijuana card and began giving him marijuana — THC for the pain and nausea, but also CBD. The dose was based on Landon’s weight. He first took it in oil form, but now takes a pill.
Once the doses started, “Landon’s (red and white blood cell) counts increased dramatically,” she says.
Six months later, encouraged by Landon’s progress, she stopped his chemotherapy treatments completely.
“Once I took the chemo out, I see these amazing results. And no more need for blood transfusion and platelet transfusions,” Riddle says. “I think that the chemo in combination with the cannabis did put him into remission and now the cannabis will keep him there.”
More than a dozen U.S. states have now completely decriminalized the act of possessing marijuana and both Colorado and Washington have made it legal to possess, sell, transport and cultivate the plant. But soon it may be legalized across the entire country following a decision Thursday by the federal government.
In a historic and significant moment in American history, last November, Colorado became the first US state to legalize marijuana for recreational use. The impact of the decision could soon ripple across the entire country with vast opportunities to educate millions on the top health benefits of marijuana.
With the passage of I-502 in the 2012 Washington State election, marijuana also became legal in Washington–not just for medical use, but also for recreational use–and Alaska, California, Connecticut, Maine, Massachusetts, Nevada, New York, Nebraska, North Carolina, Ohio, Oregon, and Vermont have all decriminalized marijuana.
Consumption and sale of marijuana is still illegal in all other states, though some cities and towns have passed local laws decriminalizing it or making it a low priority for law enforcement officers.
There are also movements in many states to legalize pot, including legalization bills introduced in many other states.
For other states to mimic the systems in Colorado and Washington, they will first have to get legalization laws on their ballots or in their state houses, which could post a challenge, he said.
After Washington state and Colorado passed laws in November 2012 legalizing the consumption and sale of marijuana for adults over 18, lawmakers in both states waited to see whether the federal government would continue to prosecute pot crimes under federal statutes in their states.
Both Colorado and Washington have been working to set up regulatory systems in order to license and tax marijuana growers and retail sellers, but have been wary of whether federal prosecutors would come after them for doing so. They are the first states to legalize pot, and therefore to go through the process of trying to set up a regulatory system.
Ruling Signals The End is Near For Marijuana Prohibition
Last Thursday, the Department of Justice announced that it would not prosecute marijuana crimes that were legal under state law, a move that could signal the end of the country’s longtime prohibition on pot is nearing. “It certainly appears to be potentially the beginning of the end,” said Paul Armantano, deputy director of the pot lobby group NORML.
The memo sent to states Thursday by the DOJ said that as long as states set up comprehensive regulations governing marijuana, there would be no need for the federal government to step in, a decision that will save the Justice Department from having to use its limited resources on prosecuting individuals for growing or smoking marijuana.
“This memo appears to be sending the message to states regarding marijuana prohibition that is a recognition that a majority of the public and in some states majority of lawmakers no longer want to continue down the road of illegal cannabis, and would rather experiment with different regulatory schemes of license and retail sale of cannabis,” Armantano said.
In 2011 the federal government decreed that marijuana had no accepted medical use use and should remain classified as a highly dangerous drug like heroin. Accepting and promoting the powerful health benefits of marijuana would instantly cut huge profits geared towards cancer treatment and the U.S. would have to admit it imprisons the population for no cause. Nearly half of all drug arrests in the United States are for marijuana.
According to MarijuanaNews.com editor Richard Cowan, the answer is because it is a threat to cannabis prohibition “…there really is massive proof that the suppression of medical cannabis represents the greatest failure of the institutions of a free society, medicine, journalism, science, and our fundamental values,” Cowan notes.
While Colorado and Washington have not yet set up their regulatory systems, both states will likely sell licenses to farmers who want to grow marijuana as well as to manufacturing plants and retail sellers. The marijuana will also likely be taxed at each stage of its growth, processing, and sale.
“In both Colorado and Washington, legalization was done by citizens with no participation by elected representatives until they had to pass laws to comply with the initiative. In other initiative states I would expect such measures – I would expect a new one in California, for instance – and roughly half the states permit this and the rest don’t.
“In the states that do have initiatives I expect efforts to get it on the ballot. The other half it will be much tougher. It’s hard to get elected representatives to do this,” Collins said.
Armantano is more optimistic about the spread of legalized pot. He compared the DOJ’s announcement to the federal government’s actions toward the end of alcohol prohibition in America a century ago, when states decided to stop following the federal ban on alcohol sales and the federal government said it would not step in and prosecute crimes.
“For first time we now have clear message from fed government saying they will not stand in way of states that wish to implement alternative regulatory schemes in lieu of federal prohibition,” Armantano said.
He predicted that within the next one to three years, five or six other states may join Colorado and Washington in legalizing the drug, setting the stage for the rest of the country to follow.
The Age of Deception is Ending
In 2003, the U.S. Government as represented by the Department of Health and Human Services filed for, and was awarded a patent on cannabinoids. The reason? Because research into cannabinoids allowed pharmaceutical companies to acquire practical knowledge on one of the most powerful antioxidants and neuroprotectants known to the natural world.
The U.S. Patent 6630507 was specifically initiated when researchers found that cannabinoids had specific antioxidant properties making them useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention.
Besides the top 10 health benefits below, findings published in the journalPLoS ONE, researchers have now have now discovered that marijuana-like chemicals trigger receptors on human immune cells that can directly inhibit a type of human immuno-deficiency virus (HIV) found in late-stage AIDS.
Recent studies have even shown it to be an effective atypical anti-psychotic in treating schizophrenia, a disease many other studies have inconsistently found it causing.
Top 10 Health Benefits of Marijuana
Cannabinoids, the active components of marijuana, inhibit tumor growth in laboratory animalsÃ‚Â and also kill cancer cells. Western governments have known this for a long time yet they continued to suppress the information so that cannabis prohibition and the profits generated by the drug industry proliferated.
THC that targets cannabinoid receptors CB1 and CB2 is similar in function to endocannabinoids, which are cannabinoids that are naturally produced in the body and activate these receptors. The researchers suggest that THC or other designer agents that activate these receptors might be used in a targeted fashion to treat lung cancer.
2. Tourette’s Syndrome
Tourette’s syndrome is a neurological condition characterized by uncontrollable facial grimaces, tics, and involuntary grunts, snorts and shouts.
Dr. Kirsten Mueller-Vahl of the Hanover Medical College in Germany led a team that investigated the effects of chemicals called cannabinols in 12 adult Tourette’s patients. A single dose of the cannabinol produced a significant reduction in symptoms for several hours compared to placebo, the researchers reported.
Marijuana is a muscle relaxant and has “antispasmodic” qualities that have proven to be a very effective treatment for seizures. There are actually countless cases of people suffering from seizures that have only been able to function better through the use of marijuana.
Since medicinal marijuana was legalized in California, doctors have reported that they have been able to treat more than 300,000 cases of migraines that conventional medicine couldn’t through marijuana.
Marijuana’s treatment of glaucoma has been one of the best documented. There isn’t a single valid study that exists that disproves marijuana’s very powerful and popular effects on glaucoma patients.
6. Multiple Sclerosis
Marijuana’s effects on multiple sclerosis patients became better documented when former talk-show host, Montel Williams began to use pot to treat his MS. Marijuana works to stop the neurological effects and muscle spasms that come from the fatal disease.
7. ADD and ADHD
A well documented USC study done about a year ago showed that marijuana is not only a perfect alternative for Ritalin but treats the disorder without any of the negative side effects of the pharmaceutical.
8. IBS and Crohn’s
Marijuana has shown that it can help with symptoms of the chronic diseases as it stops nausea, abdominal pain, and diarrhea.
Despite what you may have heard about marijuana’s effects on the brain, the Scripps Institute, in 2006, proved that the THC found in marijuana works to prevent Alzheimer’s by blocking the deposits in the brain that cause the disease.
10. Premenstrual Syndrome
Just like marijuana is used to treat IBS, it can be used to treat the cramps and discomfort that causes PMS symptoms. Using marijuana for PMS actually goes all the way back to Queen Victoria.
Mounting Evidence Suggests Raw Cannabis is Best
Cannabinoids can prevent cancer, reduce heart attacks by 66% and insulin dependent diabetes by 58%. Cannabis clinician Dr. William Courtney recommends drinking 4 – 8 ounces of raw flower and leaf juice from any Hemp plant, 5 mg of Cannabidiol (CBD) per kg of body weight, a salad of Hemp seed sprouts and 50 mg of THC taken in 5 daily doses.
Why raw? Heat destroys certain enzymes and nutrients in plants. Incorporating raw cannabis allows for a greater availability of those elements. Those who require large amounts of cannabinoids without the psychoactive effects need to look no further than raw cannabis. In this capacity, it can be used at 60 times more tolerance than if it were heated.
Raw cannabis is considered by many experts as a dietary essential. As a powerful anti-inflammatory and antioxidant, raw cannabis may be right u there with garlic and tumeric.
Marco Torres, Prevent Disease
Those Pungent Smells Oozing Out of Marijuana Buds Are Actually Giving You Clues About What Their Effects Will Be Like
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Scientists are now formally acknowledging something that Cannabis consumers have long taken for granted: aroma is associated with effect.
Plant cannabinoids —21-carbon molecules found only in Cannabis— are odorless. It’s the terpenoids —components of the plant’s “essential oils”— that create the fragrance. Terpenoids contain repeating units of a 5-carbon molecule called isoprene and are prevalent in smelly herbs such as mints and sage, citrus peel, some flowers, aromatic barks and woods.
The aroma of a given plant depends on which terpenoids predominate. They tend to be volatile molecules that readily evaporate, and they’re very potent —all it takes is a few reaching the nose to announce their presence.
Evidence that “phytocannabinoid-terpenoid interactions” enhance the therapeutic effects of cannabis was presented by Ethan Russo, MD, at a conference in Israel in 2010 and published in the August 2011 British Journal of Pharmacology. Russo, a neurologist and ethnobotanist, is senior medical adviser at GW Pharmaceuticals.
Both terpenoids and cannabinoids are secreted inside the Cannabis plant’s glandular trichomes, and they have a parent compound in common (geranyl pyrophosphate). More than 200 terpenoids have been identified in Cannabis. The most common and most studied include limonene, myrcene, alpha-pinene, linalool, beta-caryophyllene, caryophyllene oxide, nerolidol and phytol. Anecdotal evidence suggests that pinene is alerting, limonene “sunshine-y,” and myrcene sedating.
The fact that most terpenoid compounds are common components of the human diet and “generally recognized as safe” by the Food and Drug Administration has made research possible, and scientists employed by flavor and fragrances manufacturers have investigated their properties over the years. But the terpenoids “remain understudied” in terms of therapeutic potential, according to Russo.
His paper mustered all the evidence —proof in some cases, hints in others— that cannabinoids and terpenoids can work in concert to abate symptoms of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA, which kills more Americans nowadays than AIDS) and other illnesses.
Jeffrey Hergenrather, MD, president of the Society of Cannabis Clinicians, who heard Russo’s presentation in Israel, expects its publication to “generate great interest in terpenes among medical cannabis users as well as physicians.” The SCC recently began collecting data on patients’ responses to CBD-rich Cannabis. Future surveys will seek to document which other cannabinoids and which terpenoids are associated with which effects.
The “Entourage Effect”
The conference at which Russo presented his paper was held at Hebrew University, Jerusalem, where Raphael Mechoulam directs a lab, in honor of Mechoulam’s 80th birthday.
In 1999 Mechoulam co-authored a paper with Shimon Ben-Shabat suggesting that cannabinoids made in the body work by means of an “entourage effect.” They had found that the endocannabinoid 2-AG (2-arachidonoylglycerol), when administered with two related compounds, would bind more readily at the cannabinoid receptors and exert more pronounced behavioral effect on mice.
To pharmacologists who customarily designed experiments aimed at finding the active ingredient, this had heavy implications. Mechoulam spelled them out: “Biochemically active natural products, from either plant or animal origin, are in many instances accompanied by chemically related though biologically inactive constituents. Very seldom is the biological activity of the active constituent assayed together with inactive ‘entourage’ compounds. Investigations of the effect of the active component in the presence of its ‘entourage’ compounds may lead to results that differ from those observed with the active component only.”
In 2001 John McPartland and Russo published a paper in the Journal of Cannabis Therapeutics applying the “entourage” concept to the plant itself. “Good evidence shows that secondary compounds in cannabis may enhance the beneficial effects of THC… and reduce THC-induced anxiety, cholinergic deficits, and immunosuppresion,” they wrote. “Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity.”
Dr. Christina Sanchez — a molecular biologist at Compultense University in Madrid, Spain — explains how THC kills cancer cells
1) CBD is an antibacterial and slows bacterial growth. This is significant for those of us who are dealing with an imbalance of bad bacteria which can cause health problems such as gum disease, heart disease, and intestinal issues.
2) When you take CBD, it does not cause the typical “high” associated with cannabis. In fact, CBD works as a partner with THC to balance its psychoactive effects. My personal experience with high CBD cannabis medicines is that they leave me clear-headed, positive, energetic, and relaxed. I describe this state as feeling like myself.
3) CBD reduces inflammation. Let me repeat that, CBD reduces inflammation!! Inflammation in the body causes disease. Less inflammation, less disease.
4) CBD promotes bone growth. How many people do you know that have a musculoskeletal deficiency who would benefit from a non-toxic, natural medicine for bone growth? When I first learned that taking cannabis could keep my bones strong I think I may have teared up. There are not too many things I wouldn’t do to be able to age without a degenerating, scoliotic spine so to know that this is one of the potential benefits of the CBD medicine that I am taking leaves me feeling incredibly grateful.
5) CBD reduces function in the immune system. If you suffer with an autoimmune disorder calming your overactive immune system down is vital for your continuing health. When my immune system is overactive I have all sorts of funky things happen to me: migraines, body pain, numb fingers and toes, and so on. Having a medicine that can help me regulate immune function is more valuable to me than the words can find.
6) CBD relieves anxiety. How lovely is that? I’m a relatively even tempered person, I think, but I do deal with anxiety. I am aware that this is a side effect of having chronic pain but that doesn’t make it any easier to deal with. CBD’s allow me to relax and feel like somebody who can handle the regular stresses of life during spells of anxiety.
7) CBD relieves pain. This is by far the most dramatic thing that CBD does for me personally. To be able to have relief from the pain that is debilitating you and locking you within your body feels like absolute freedom.
8) CBD suppresses muscles spasms. I actually had to think about the last time I had muscle spasms because it has been a while. I used to get them all the time before I started using medicinal cannabis but now they are something that I used to get.
9) CBD reduces blood sugar levels. High blood sugar can cause havoc in the body. Ask any person with diabetes and they will tell you that regulating your blood sugar is vital to one’s health and vitality.
10) CBD reduces seizures. I don’t have personal experience with this one but I do know of people who have been able to reduce and in some cases stop the seizures that they experience by using high CBD cannabis.
11) CBD inhibits cancer cell growth. Oh, did I mention it fights cancer?
I am just scratching the surface here of what CBDs can do for the body but that is a pretty impressive list, isn’t it?
How does one effectively get CBDs in their body? You’ll have to first seek out cannabis strains and medicines that contain high CBD. This will require a little homework and probably a little shopping around to find the one that is right for you. The most superior ways that I have found to get CBD through cannabis is by regularly taking it orally or applying it topically to the skin.
I would just like to add that my life drastically changed for the better when I found cannabis medicines with high CBDs. Thankfully I live in a part of the world that allows me to have safe access to this medicine.
May you have safe access to CBD too.
MORGANTOWN, WV — Non-steroidal anti-inflammatory drugs (NSAID), such as ibuprofen, are among the most widely used analgesic substances in the world. However, the consumption of these products is associated with various adverse and life-threatening side-effects such as heart-attack, stroke, and internal bleeding.
In fact, according to a 2001 analysis, in the United States alone, “gastrointestinal complications induced by non-steroidal anti-inflammatory drugs (NSAIDs) cause more than 100,000 hospitalizations and an estimated 16,500 deaths annually.”
Could these adverse gastrointestinal effects be offset by cannabis? A just published study in the European Journal of Pharmacology indicates that the most likely answer is ‘yes.’
Researchers at West Virginia University assessed the impact of THC administration in an animal model of NSAID-induced gastric inflammation. Investigators reported that low doses of THC provided gastroprotective effects, significantly attenuating gastric hemorrhages and lesions.
They concluded: “The results of the present study suggest that delta-9-THC … may also possess gastroprotective effects in NSAID using patients. … As current antacid regimens may be associated with undesirable effects, such as reduced bone density, increased risk of bacterial infection, and vitamin deficiencies, other approaches to prevent NSAID-induced gastric ulcers are needed. In addition to their gastroprotective effects, cannabinoids produce other beneficial effects, including pain reduction. … Thus, cannabinoids may have the added benefit of reducing the effective analgesic dose of NSAIDs, as well as reducing the incidence of NSAID-induced gastric ulcers.”
Full text of the study, “Acute delta-9-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice,” appears online in the European Journal of Pharmacology.
Please donate to Phoenix Tears. People are serving 3 year jail sentences just for helping dying kids. I am not connected with Phoenix Tears in any way.
This 100 dollar device can be used to make the oil and more carefully control the temperature: Food Immersion Temperature Controller
Phoenix Tears Foundation 7931 S Broadway #230 Littleton, CO 80122 (303) 719-8658 email@example.com
– Thanks – ED]
Cannabis Oil and Cancer
By Mark Sircus Ac., OMD
The medical science is strongly in favor of THC laden hemp oil as a primary cancer therapy, not just in a supportive role to control the side effects of chemotherapy. The International Medical Verities Association is putting hemp oil on its cancer protocol. It is a prioritized protocol list whose top five items are magnesium chloride, iodine, selenium, Alpha Lipoic Acid and sodium bicarbonate. It makes perfect sense to drop hemp oil right into the middle of this nutritional crossfire of anti cancer medicines, which are all available without prescription.
Hemp oil has long been recognized as one of the most versatile and beneficial substances known to man. Derived from hemp seeds (a member of the achene family of fruits) it has been regarded as a superfood due to its high essential fatty acid content and the unique ratio of omega3 to omega6 and gamma linolenic acid (GLA) – 2:5:1. Hemp oil, is known to contain up to 5% of pure GLA, a much higher concentration than any other plant, even higher than spirulina. For thousands of years, the hemp plant has been used in elixirs and medicinal teas because of its healing properties and now medical science is zeroing in on the properties of its active substances.
Both the commercial legal type of hemp oil and the illegal THC laden hemp oil are one of the most power-packed protein sources available in the plant kingdom. Its oil can be used in many nutritional and trans-dermal applications. In other chapters in my Winning the War on Cancer book we will discuss in-depth about GLA and cancer and also the interesting work of Dr. Johanna Budwig. She uses flax seed oil instead of hemp oil to cure cancer – through effecting changes in cell walls – using these omega3 and omega6 laden medicinal oils.
Actually there is another way to use medical marijuana without smoking the leaf. According to Dr. Tod H. Mikuriya, “The usual irritating and toxic breakdown products of burning utilized with smoking are totally avoided with vaporization. Extraction and inhaling cannabinoid essential oils below ignition temperature of both crude and refined cannabis products affords significant mitigation of irritation to the oral cavity, and tracheobronchial tree from pyrollytic breakdown products.[iii]
Dr. Mikuriya continues saying “The usual irritating and toxic breakdown products of burning utilized with smoking are totally avoided with vaporization. Extraction and inhaling cannabinoid essential oils below ignition temperature of both crude and refined cannabis products affords significant mitigation of irritation to the oral cavity, and tracheobronchial tree from pyrollytic breakdown products.”[iv]
Rick Simpson, the man in the above mentioned videos, has been making hemp oil and sharing it with friends and neighbors without charging for it. In small doses, he says, it makes you well without getting you high. “Well you can’t deny your own eyes can you?” Simpson asks. “Here’s someone dying of cancer and they’re not dying anymore. I don’t care if the medicine comes from a tomato plant, potato plant or a hemp plant, if the medicine is safe and helps and works, why not use it?” he asks.
When a person has cancer and is dying this question reaches a critical point. The bravery of Rick Simpson from Canada in showing us how to make hemp oil for ourselves offers many people a hope that should be increasingly appreciated as money dries up for expensive cancer treatments. We are going to need inexpensive medicines in the future and there is nothing better than the ones we can make reasonably cheaply ourselves.
For most people in the world it is illegal so the choice could come down to breaking the law or dying. There is no research to indicate what advantages oral use of hemp oil vs. vaporization but we can assume that advantage would be nutritional with oral intake. Dr. Budwig Below work would sustain this point of view especially for cancer patients.
According to Dr. Robert Ramer and Dr. Burkhard Hinz of the University of Rostock in Germany medical marijuana can be an effective treatment for cancer.[v] Their research was published in the Journal of the National Cancer Institute Advance Access on December 25th of 2007 in a paper entitled Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1.
The biggest contribution of this breakthrough discovery, is that the expression of TIMP-1 was shown to be stimulated by cannabinoid receptor activation and to mediate the anti-invasive effect of cannabinoids. Prior to now the cellular mechanisms underlying this effect were unclear and the relevance of the findings to the behavior of tumor cells in vivo remains to be determined.
Marijuana cuts lung cancer tumor growth in half, a 2007 Harvard Medical School study shows. The active ingredient in marijuana cuts tumor growth in lung cancer in half and significantly reduces the ability of the cancer to spread, say researchers at Harvard University who tested the chemical in both lab and mouse studies.
This is the first set of experiments to show that the compound, Delta-tetrahydrocannabinol (THC), inhibits EGF-induced growth and migration in epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer cell lines. Lung cancers that over-express EGFR are usually highly aggressive and resistant to chemotherapy. THC that targets cannabinoid receptors CB1 and CB2 is similar in function to endocannabinoids, which are cannabinoids that are naturally produced in the body and activate these receptors.
“The beauty of this study is that we are showing that a substance of abuse, if used prudently, may offer a new road to therapy against lung cancer,” said Anju Preet, Ph.D., a researcher in the Division of Experimental Medicine. Acting through cannabinoid receptors CB1 and CB2, endocannabinoids (as well as THC) are thought to play a role in variety of biological functions, including pain and anxiety control, and inflammation.
Researchers reported in the August 15, 2004 issue of Cancer Research, the journal of the American Association for Cancer Research, that marijuana’s constituents inhibited the spread of brain cancer in human tumor biopsies.[vii] In a related development, a research team from the University of South Florida further noted that THC can also selectively inhibit the activation and replication of gamma herpes viruses. The viruses, which can lie dormant for years within white blood cells before becoming active and spreading to other cells, are thought to increase one’s chances of developing cancers such as Kaposi’s Sarcoma, Burkitt’s lymphoma and Hodgkin’s disease.
In 1998, a research team at Madrid’s Complutense University discovered that THC can selectively induce programmed cell death in brain tumor cells without negatively impacting surrounding healthy cells. Then in 2000, they reported in the journal Nature Medicine that injections of synthetic THC eradicated malignant gliomas (brain tumors) in one-third of treated rats, and prolonged life in another third by six weeks.
Led by Dr. Manuel Guzman the Spanish team announced they had destroyed incurable brain cancer tumors in rats by injecting them with THC. They reported in the March 2002 issue of “Nature Medicine” that they injected the brains of 45 rats with cancer cells, producing tumors whose presence they confirmed through magnetic resonance imaging (MRI). On the 12th day they injected 15 of the rats with THC and 15 with Win-55,212-2 a synthetic compound similar to THC.
Researchers at the University of Milan in Naples, Italy, reported in the Journal of Pharmacology and Experimental Therapeutics that non-psychoactive compounds in marijuana inhibited the growth of glioma cells in a dose-dependent manner, and selectively targeted and killed malignant cells through apoptosis. “Non-psychoactive CBD produce[s] a significant anti-tumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent.”
The first experiment documenting pot’s anti-tumor effects took place in 1974 at the Medical College of Virginia at the behest of the U.S. government. The results of that study, reported in an Aug. 18, 1974, Washington Post newspaper feature, were that marijuana’s psychoactive component, THC, “slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent.”
Funded by the National Institute of Health to find evidence that marijuana damages the immune system, found instead that THC slowed the growth of three kinds of cancer in mice — lung and breast cancer, and a virus-induced leukemia. The DEA quickly shut down the Virginia study and all further cannabis/tumor research even though the researchers “found that THC slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent.”
“Antineoplastic Activity of Cannabinoids,” an article in a 1975 Journal of the National Cancer Institute reports, “Lewis lung adenocarcinoma growth was retarded by the oral administration of tetrahydrocannabinol (THC) and cannabinol (CBN)” — two types of cannabinoids, a family of active components in marijuana. “Mice treated for 20 consecutive days with THC and CBN had reduced primary tumor size.”
Marijuana relieves pain that narcotics like morphine and OxyContin have hardly any effect on, and could help ease suffering from illnesses such as multiple sclerosis, diabetes and cancer.
According to Devra Davis in her book Secret History of the War on Cancer, 1.5 million lives have been lost because Americans failed to act on existing knowledge about the environmental causes of cancer. It is impossible to calculate the added deaths from suppressed ‘cancer cures’ but we do know of the terrible suffering of hundreds of thousands of people who have been jailed for marijuana use.
Hemp oil with THC included has the making of a primary cancer treatment, which even alone seems to have a great chance of turning the tide against cancer tumors. It has the added advantage of safety, ease of use, lack of side effects and low cost if one makes it oneself. Surrounded by other medicinal anti-cancer substances in a full protocol it’s hard to imagine anyone failing and falling in their war on cancer.
THC should be included in every cancer protocol.
Sodium bicarbonate is another excellent anti tumor substance that reduces tumors but is much more difficult to administer than THC hemp oil. Cannabinoids are able to pass through all barriers in the body like Alpha Lipoic Acid so simple oral intake is sufficient. With bicarbonate we need intravenous applications and often even this is not sufficient, often we have to use catheters and few doctors in the world are willing to administer this way.
In the end all cancer treatments that are not promoted by mainstream oncology are illegal. No licensed doctor is going to claim that are curing cancer with sodium bicarbonate though they will treat people with cancer explaining they are balancing pH or some other metabolic profile with this common emergency room medicine found also most kitchens of the world. More than several states have passed laws making medical marijuana legal but the federal government will not relax and let people be free to choose their treatments even if their lives depend on it.
Davis notes that the cowardice of research scientists, who publish thoroughly referenced reports but pull their punches at the end, by claiming that more research needs to be done before action can be taken. Statements like these are exploited by industry that buys time to make much more money. It is a deliberate attempt that creates wholesale public doubt from small data gaps and remaining scientific uncertainties.
They have done that with everything right up to and including sunlight. Everything is thought to be dangerous except the pharmaceutical drugs which are the most dangerous substances of all. Stomach wrenching chemotherapy and the death principle of radiation are legal yet safe THC laden hemp oil is not.
It is legal for doctors to attack people with their poisons but you can go to jail for trying to save yourself or a loved one from cancer with the oil of a simple garden weed. Our civilization has put up with this insanity but there is a great price being paid. In a mad medical world people die that need not and this is a terrible sadness that has destroyed the integrity and ethics of modern medicine.
The science for the use of hemp oil is credible, specific fact-based, and is documented in detail. There is absolutely no reason to not legalize medical marijuana and create an immediate production and distribution of THC hemp oil to cancer patients. Unfortunately we live in a world populated with governments and medical henchmen who would rather see people die cruel deaths then have access to a safe and effect cancer drug.
Meanwhile the Food and Drug Administration approved Genentech’s best-selling drug, Avastin, as a treatment for breast cancer, in a decision, according to the New York Times, “that appeared to lower the threshold somewhat for approval of certain cancer drugs. The big question was whether it was enough for a drug temporarily to stop cancer from worsening — as Avastin had done in a clinical trial — or was it necessary for a drug to enable patients to live longer, which Avastin had failed to do. Oncologists and patient advocates were divided, in part because of the drug’s sometimes severe side effects.”
The differences between Avastin and hemp oil are huge. First Avastin will earn Genentech hundreds of millions where THC hemp oil will earn no one anything. Second there are no severe or even mild side effects to taking hemp oil and lastly it is not a temporary answer but a real solution. Certainly hemp oil will ensure a longer life.
The rules and regulations concerning cannabis do not coincide with the research into the plant and its inherent pharmacological properties. When an institution of authority identifies a substance as a “poison” or “medicine” through the influential force that is rhetoric or propaganda, the stigma then predisposes individuals to unite in confirmation of the former or the latter, rather than conceding to the existence or manifestation of both.
Cannabis, or Marijuana is classified as a Schedule I controlled substance under the Controlled Substances Act (CSA). As a Schedule I drug, marijuana is classified under the following criteria:
A. The drug has a high potential for abuse.
B. The drug has no currently accepted medical use in treatment in the United States
C. There is a lack of accepted safety for use of the drug under medical supervision
Having this classification attached to the plant, includes Cannabis with heroin, lysergic acid diethylamide (LSD), and methaqualone (Quaaludes).
Federal law assigns every drug to a schedule which purports to determine the drugs medicinal value verses its potential for abuse. Because marijuana is classified as a Schedule I drug, the law provides that does not have an acceptable medicinal value because it has no medical value while being highly addictive.
Physicians may exercise their right to free speech by recommending the use of marijuana under the First Amendment; however federal law does not make exclusions for a doctor to “prescribe” marijuana.
Regardless of state laws to the contrary, there is no such thing as “medical” marijuana under Federal law. The U.S. Federal government has also prohibited Cannabis under the Interstate Commerce Clause. Additionally, under the Supremacy Clause, any state law in conflict with federal law is not valid.
Federal Marijuana Sentencing Law & Federal Sentencing Guidelines for Marijuana Offenses
The sentencing guidelines allocate a range for suggested sentences based on several mitigating or aggravating factors including: the quantity of cannabis involved in the offense and the defendant’s criminal record. Every marijuana conviction under Federal law can potentially result in imprisonment
For any federal sentence imposed that requires imprisonment, the defendant must serve a minimum of 85% of that sentence before early parole or “good time” is considered.
Larger amount of marijuana typically come with harsher minimum mandatory sentences. For instance, cultivation of 100 plants or the possession of 100 kg or more results in a five year minimum mandatory prison sentence under federal law.
The minimum mandatory sentence is doubled for this offense if the defendant has any prior conviction for felony drug charges. The cultivation of 1000 plants or possession of 1,000 kilograms of Cannabis produces a ten-year minimum mandatory sentence. An offender with a prior conviction for any drug offense will result in a twenty-year minimum mandatory sentence. With two prior felony drug convictions, the defendant faces a life sentence.
How can our leaders conceivably testify without perjuring themselves, that cannabis has no medicinal value while at the same time they hold a patent that describes in great detail so many of the demonstrated medicinal qualities of Cannabis?
Even with Prohibition in Effect, The United States Federal Government Owns a patent on Cannabis…
United States Patent # 6,630,507
Hampson , et al.
Filing date: Feb 2, 2001
Issue date: Oct 7, 2003
Application number: 09/674,028
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH.sub.3, and COCH.sub.3. ##STR1##
“The prestige of government
has undoubtedly been lowered considerably
by the Prohibition law.
For nothing is more destructive
of respect for the government and
the law of the land
than passing laws which cannot be enforced”
― Albert Einstein
The Medical and Scientific Research
I would like to share with you some of the existing research between cannabis and cancers of the immune system (leukemia/lymphoma). This information is specific to Jurkat leukemia cell lines… which is a CD4+ T-cell Acute Lymphoblastic Leukemia… This is the same lineage discovered in Mykayla’s leukemia. Brave Mykayla’s specific type of cancer has a large volume of proven science behind cannabis being an effective treatment because scientists discovered that immune system cells have a SPECIFIC cb2 receptor on them that cause apoptosis (cell death)
Δ9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
THC induces apoptosis in Jurkat (t-cell acute lymphoblastic leukemia) cells via three different mechanisms. (1) THC binds to CB1 and CB2, and leads to ceramide synthesis by serine palmitoyltransferase. (2) Ceramide enters the mitochondria and results in cytochrome c leakage into the cytosol. (3) Cytochrome c combines with Apaf-1, caspase 9, and forms the apoptosome. (4) The apoptosome converts procaspase 3 to active caspase 3, resulting in apoptosis. THC also activates the extrinsic pathway (caspases 8 and 10), and inhibits Raf/Mek/Erk pathway. The inhibition of the cell survival pathway leads to dephosphorylation of Bad, and translocation of this Bcl-2 protein into the mitochondria, and subsequently to apoptosis.
Targeting cannabinoid receptors to treat leukemia: Role of cross-talk between extrinsic and intrinsic pathways in Δ9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells
Targeting cannabinoid receptors has recently been shown to trigger apoptosis and offers a novel treatment modality against malignancies of the immune system. However, the precise mechanism of apoptosis in such cancers has not been previously addressed. In this study, we used human Jurkat leukemia cell lines with defects in intrinsic and extrinsic signaling pathways to elucidate the mechanism of apoptosis induced by Δ9-tetrahydrocannabinol (THC). We observed that Jurkat cells deficient in FADD or caspase-8 were partially resistant to apoptosis, while dominant-negative caspase-9 mutant cells were completely resistant to apoptosis. Use of caspase inhibitors confirmed these results. Furthermore, overexpression of Bcl-2 rendered the cells resistant to THC at early time points but not upon prolonged exposure. THC treatment led to loss of Δψm, in both wild-type and FADD-deficient Jurkat cells thereby suggesting that THC-induced intrinsic pathway was independent of FADD. THC treatment of wild-type Jurkat cells caused cytochrome c release, and cleavage of caspase-8, -9, -2, -10, and Bid. Caspase-2 inhibitor blocked THC-induced caspase-3 in wild-type Jurkat cells but not loss of Δψm. Together, these data suggest that the intrinsic pathway plays a more critical role in THC-induced apoptosis while the extrinsic pathway may facilitate apoptosis via cross-talk with the intrinsic pathway.
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease:
The current study demonstrates that targeting CB2 receptors to induce apoptosis may constitute a novel approach to treating malignancies of the immune system. The advantage in using CB2 receptor agonists is that they do not exhibit psychoactive properties. Also, because CB2 receptors are expressed exclusively on immune cells, use of CB2 receptor agonists will not be toxic to non-immune cells. Thus, further research on CB2 receptor agonists to target transformed immune cells could lead to discovery of a new class of highly selective anticancer agents
Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression
In the current study, we examined the effects of the nonpsychoactive cannabinoid, cannabidiol, on the induction of apoptosis in leukemia cells. Exposure of leukemia cells to cannabidiol led to cannabinoid receptor 2 (CB2)-mediated reduction in cell viability and induction in apoptosis. Furthermore, cannabidiol treatment led to a significant decrease in tumor burden and an increase in apoptotic tumors in vivo. From a mechanistic standpoint, cannabidiol exposure resulted in activation of caspase-8, caspase-9, and caspase-3, cleavage of poly(ADP-ribose) polymerase, and a decrease in full-length Bid, suggesting possible cross-talk between the intrinsic and extrinsic apoptotic pathways. The role of the mitochondria was further suggested as exposure to cannabidiol led to loss of mitochondrial membrane potential and release of cytochrome c. It is noteworthy that cannabidiol exposure led to an increase in reactive oxygen species (ROS) production as well as an increase in the expression of the NAD(P)H oxidases Nox4 and p22phox. Furthermore, cannabidiol-induced apoptosis and reactive oxygen species (ROS) levels could be blocked by treatment with the ROS scavengers or the NAD(P)H oxidase inhibitors. Finally, cannabidiol exposure led to a decrease in the levels of p-p38 mitogen-activated protein kinase, which could be blocked by treatment with a CB2-selective antagonist or ROS scavenger. Together, the results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22phox expression, may be a novel and highly selective treatment for leukemia.
Cannabinoid receptor-mediated regulation of intracellular calcium by Δ9-tetrahydrocannabinol in resting T cells
Cannabinoids exhibit broad immune modulating activity by targeting many cell types within the immune system, including T cells, which exhibit sensitivity, as evidenced by altered activation, proliferation, and cytokine expression. As a result of the critical role calcium plays in T cell function coupled with previous findings demonstrating disruption of the calcium-regulated transcription factor, nuclear factor of activated T cells, by cannabinoid treatment, the objective of the present investigation was to perform an initial characterization of the role of the cannabinoid receptors in the regulation of the intracellular calcium concentration ([Ca2+]i) by Δ9-tetrahydrocannabinol (Δ9-THC) in T lymphocytes. Here, we demonstrate that Δ9-THC robustly elevates [Ca2+]i in purified murine splenic T cells and in the human peripheral blood acute lymphoid leukemia (HPB-ALL) human T cell line but only minimally elevates [Ca2+]i in Jurkat E6-1 (dysfunctional cannabinoid receptor 2-expressing) human T cells. Removal of extracellular calcium severely attenuated the Δ9-THC-mediated rise in [Ca2+]i in murine splenic T cells and HPB-ALL cells. Pretreatment with cannabinoid receptor antagonists, SR144528 and/or SR141716A, led to an attenuation of Δ9-THC-mediated elevation in [Ca2+]i in splenic T cells and HPB-ALL cells but not in Jurkat E6-1 cells. Furthermore, pretreatment of HPB-ALL cells with SR144528 antagonized the small rise in [Ca2+]i elicited by Δ9-THC in the absence of extracellular calcium. These findings suggest that Δ9-THC induces an influx of extracellular calcium in resting T cells in a cannabinoid receptor-dependent manner.
Cannabinoids: potential anticancer agents
Cannabinoids — the active components of Cannabis sativa and their derivatives — exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In addition, these compounds have been shown to inhibit the growth of tumour cells in culture and animal models by modulating key cell-signalling pathways. Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies. So, could cannabinoids be used to develop new anticancer therapies?
“Prohibition… goes beyond the bounds of reason in that it attempts to control mans’ appetite through legislation and makes a crime out of things that are not even crimes… A prohibition law strikes a blow at the very principles upon which our Government was founded.”
― Abraham Lincoln
Thanks to the available findings of a 2006 study showing that cannabis actually reduces the number of cancer cells, medical marijuana users can now feel even better about the widely abolished pain relief ingredient found in the plant. The relationship between marijuana and cancer has always been up for debate, but with the use of a specially crafted oil made from the buds of the Cannabis Sativa plant, scientists confirmed that the plant’s primary psychoactive chemical tetrahydrocannabinol (THC) destroys any and all malignant cancer cell growths in several patients. Details on the marijuana and cancer prevention connection aren’t exactly known, but further, more extensive testing will reveal exactly what may be causing this seemingly miracle cure.
Shedding Some Light on the Marijuana and Cancer Relationship
Back in 2006, the study was developed by a team of medical researchers at the Virginia Commonwealth University’s Pharmacology and Toxicology department on leukemia patients. The researchers essentially outlined that if taken daily for an extended period of time, cannabis oil actually reverses the growth of cancer and possibly leads to remission in the patient – with zero added side effects. Typically when a leukemia patient enters a hospital for admission and treatment, they are given a very extensive chemotherapy treatment, usually paired with a radiological treatment. Instead of considering any possible treatment involving marijuana and cancer, doctors use these not only ineffective, but also dangerous treatments. Cannabis, on the other hand, as shown in the study, has virtually no side effects. It is especially safe and effective when administered in a clean, medically sound environment and in the form of oil.
Other studies have been made over the past decades much like this one: Manuel Guzman located in Madrid, Spain discovered that cannabinoids substantially inhibit the growth of tumors in a variety of lab animals. In the study he also found that not one of these tested animals endured any kind of side effects seen in many similar chemotherapy treatments. It is becoming increasingly clear that you can sidestep any of the misery associated with traditional cancer treatments and embrace the potent, effective healing powers of THC – not to forget about the positive attributes surrounding cannabis’ other primary cannabinoid, cannabidiol (CBD).
If the results don’t appeal to you, then maybe the 2,500 total studied patients throughout these 37 controlled studies will blow the lid on the myth that cannabis is and can only be used as a “dangerous” drug. None of the patients reported any kind of adverse side effects from the use of THC and based medication – further adding to the benefits of medical marijuana and strengthening the positive connection between marijuana and cancer.
The real irony in the situation here? The combined governments of the world are the primary authority behind more than 30 studies like these completed throughout the years – and kept them secret from the general public. It wouldn’t be very conducive for our government if word got out that a schedule 1 narcotic could actually help people.